The more we know empirically about the world, the more faith has become necessary. This is true on the level of both microbiology and physics as well as on the intergalactic level of astronomy. Empirical knowledge of the workings and character of physical life only keeps providing more evidence of our inability to find the rock-bottom reality of our material existence. So while our senses tell us that we live in a world that renders us meaningless and insignificant and that seems to defy our best efforts to make it intelligible, as if it were being perpetually made by a God too busy spinning off his many life forms to pay attention to our puny human lives, ...and have the audacity, bordering on insanity, to believe that our actions matter, that we can and should act on the world’s behalf.

George Handley, "Biocentrism at Sea"